the uses of penicillin and side effects

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Pharmacological treatment using antibiotics penicillin, penicillin is bactericidal and works by inhibiting cell wall synthesis. this article will talk about  the uses of penicillin and side effects The drug diffuses well dijaringan and human body fluids, but penetration into the cerebrospinal fluid poorly unless the lining of the brain is excreted into the urine infection.obat the therapeutic level.  

Probenecid inhibits renal tubular excretion of penicillin by making higher blood levels and longer working period. The most important side effect is a reaction that can cause urticaria, and sometimes can be fatal anaphylactic reactions. Patients who are allergic to penicillin usually an allergy to all penicillin derivatives as hypersensitivity determined by the basic structure of penicillin. Encephalopathy due to cerebral irritation is a side effect that is rare but serious. This can occur in excessive doses or normal dose in patients with renal failure. Penicillin should not be administered intrathecally as this can cause encephalopathy which may be fatal.
     

          Benzylpenicillin (penicillin G) This drug is the first line of syphilis, effective for the treatment of streptococcal infections, pneumonia, syphilis, tetanus, and gonococcus, should be considered for patients who are hypersensitive to penicillin and impaired renal function. For patients who can not tolerate oral tetracycline penicillin can use as a medicine options. Keep in mind that this drug can be damaged when given orally, because the absorption of orally can be destroyed by stomach acid, therefore this drug should be used parenterally. Drug interactions that may occur due to the use of the drug penicillin is the drug when used in conjunction with antacids, anticoagulants, urikosurika, sitotoksika, and oral contraceptives.

      Common side effects are allergic reactions such as urticaria, fever, joint pain, angioudem, leukopenia, thrombocytopenia, anaphylactic shock in patients who are allergic, and diarrhea on oral administration. For patients who are pregnant this drug belongs to the category of risk factor B (the study of the reproductive system of laboratory animals show no risk to the fetus, but there are no controlled studies in pregnant women or animal reproductive system experiments that showed adverse effects in the first trimester of pregnancy) dosing for patients with syphilis: slow intravenous injection, intramuscular or infusion, 1.2 g / haridalam 4 divided doses, if necessary can be increased 2.4 g / day or more. Premature and newborn infants 50 mg / kg in  2 divided doses; infants 1-4 weeks of 75 mg / kg / day in 4 divided doses (higher doses may be needed). The generic name of this drug is benzathine penicillin G, while the trade name is penisili G procaine, and Penatur LA.

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